Global impact of somatic structural variation on the DNA methylome of human cancers.

Yiqun ZhangLixing YangMelanie KucherlapatiAngela HadjipanayisAngeliki PantaziChristopher A BristowEunjung Alice LeeHarshad S MahadeshwarJiabin TangJianhua ZhangSahil SethSemin LeeXiaojia RenXingzhi SongHuandong SunJonathan SeidmanLovelace J LuquetteRuibin XiLynda ChinAlexei ProtopopovPeter J ParkRaju KucherlapatiChad J Creighton

Published in: Genome biology (2019)

Genomic rearrangement appears to have a major role in shaping the cancer DNA methylome, to be considered alongside commonly accepted mechanisms including histone modifications and disruption of DNA methyltransferases.

Keyphrases

circulating tumor
cell free
single molecule
endothelial cells
nucleic acid
papillary thyroid
dna methylation
circulating tumor cells
squamous cell carcinoma
genome wide