An innovative lab-scale production for a novel therapeutic DNA vaccine candidate against rheumatoid arthritis.

Juan LongXiao ZhaoFei LiangYang ZengNan LiuYuying SunYongzhi Xi

Published in: Journal of biological engineering (2024)

The proposed innovative downstream process for the pcDNA-CCOL2A1 vaccine can not only provide a large-scale high-quality supercoiled plasmid DNA for preclinical research but also facilitate further pilot-scale and even industrial-scale production of pcDNA-CCOL2A1 vaccine.

Keyphrases

rheumatoid arthritis
circulating tumor
cell free
single molecule
escherichia coli
crispr cas
stem cells
disease activity
randomized controlled trial
nucleic acid
ankylosing spondylitis
cell therapy
bone marrow
mesenchymal stem cells
systemic sclerosis
idiopathic pulmonary fibrosis