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The extra domain A of fibronectin facilitates osteoclastogenesis in radicular cysts through vascular endothelial growth factor.

Jing-Wen YangJ H JiangH C WangC Y Li
Published in: International endodontic journal (2019)
In fibrous capsules of radicular cysts, the alternatively spliced isoform EDA + FN generated by fibroblasts stimulated VEGF expression via an autocrine effect and then facilitated osteoclastogenesis. Both blockage of VEGF and EDA exon knockout could be used to inhibit bone destruction.
Keyphrases
  • vascular endothelial growth factor
  • bone loss
  • endothelial cells
  • poor prognosis
  • lps induced
  • bone mineral density
  • extracellular matrix
  • soft tissue
  • bone regeneration
  • long non coding rna
  • type iii