Considerable studies have given convincing evidence of a forefront position for vascular aging in preventing cardiovascular disease. Various functions of Long non-coding RNAs (lncRNAs) are becoming increasingly distinct in aging-related diseases. This study aims at a better insight into the expression profile and mechanisms of lncRNAs in vascular senescence. High-throughput sequencing was used to detect the differential expression (DE) of lncRNAs and mRNAs in the aorta of 96 W and 8 W-old mice, while 1423 lncRNAs and 80 mRNAs were differentially expressed. By performing GO and KEGG enrichment analysis, we found that DE lncRNAs were mainly involved in purine metabolism and cGMP-PKG signaling pathways. In addition, a co-expression functional network of DE lncRNAs and DE mRNAs was constructed, and ENSMUST00000218874 could interact with 41 DE mRNAs, suggesting that it may play an essential role in vascular senescence. This study reveals DE lncRNAs in naturally aging vascular, which may provide new ideas and targets for aging-related cardiovascular diseases.
Keyphrases
- genome wide analysis
- long non coding rna
- cardiovascular disease
- network analysis
- poor prognosis
- genome wide identification
- dna damage
- signaling pathway
- endothelial cells
- pulmonary artery
- nitric oxide
- type diabetes
- single cell
- skeletal muscle
- coronary artery
- dna methylation
- genome wide
- metabolic syndrome
- insulin resistance
- adipose tissue
- endoplasmic reticulum stress
- binding protein