Association of Intraventricular Fibrinolysis With Clinical Outcomes in Intracerebral Hemorrhage: An Individual Participant Data Meta-Analysis.

Joji B Kuramatsu Stefan T Gerner Wendy C ZiaiJürgen BardutzkyJochen A Sembill Maximilian I Sprügel Anne MrochenKathrin KölblMalathi RamRadhika AvadhaniGuido J Falcone Magdy H Selim Vasileios-Arsenios Lioutas Matthias Endres Sarah Zweynert Peter Vajkoczy Peter Arthur Ringleb Jan Christoph Purrucker Jens Volkmann Hermann Neugebauer Frank Erbguth Peter Dieter SchellingerUlrich J KnappeGereon R FinkChristian DohmenJens MinnerupHeinz Reichmann Hauke Schneider Joachim Röther Gernot ReimannMichael SchwarzHansjörg Bäzner Joseph Claßen Dominik Michalski Otto W Witte Albrecht Günther Gerhard F Hamann Hannes Lücking Arnd DoerflerMuhammad Fawad IshfaqJason J Chang Fernando D Testai Daniel Woo Andrei V AlexandrovDimitre StaykovNitin Goyal Georgios Tsivgoulis Kevin Navin Sheth Issam A Awad Stefan Schwab Daniel F Hanley Hagen B Huttnernull null

Published in: Stroke (2022)

As compared to standard of care, the administration of IVF in patients with acute hydrocephalus caused by intracerebral and intraventricular hemorrhage was significantly associated with improved functional outcome at 6 months. The treatment effect was linked to an early time window <48 hours, specifying a target population for future trials.

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