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The Difficulty in Defining the True High-Risk Smoldering Myeloma.

Niels WeinholdLeo Rasche
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Early intervention trials have been initiated for the precursor disease smoldering myeloma (SMM). A recent study showed that genomic complexity varies widely among treated high-risk SMM patients and is associated with response to triplet therapy, suggesting that established clinical risk scores often fail to discriminate between stable and aggressive disease.
Keyphrases
  • newly diagnosed
  • randomized controlled trial
  • multiple myeloma
  • prognostic factors
  • copy number
  • stem cells
  • genome wide
  • energy transfer