ASPP2 Upregulation as a Novel Approach to TGF-β2-Induced Proliferative Vitreoretinopathy In Vivo and In Vitro .

Xiao-Li Chen Yankun YueHaiwei WangLu Liu

Published in: Current eye research (2024)

ASPP2 upregulation inhibited the EMT and autophagy process caused by TGF-β in ARPE-19 cells. Correspondingly, upregulation of ASPP2 alleviated intraocular fibrosis and protected visual function in PVR rats.

Keyphrases

signaling pathway
poor prognosis
induced apoptosis
cell proliferation
transforming growth factor
epithelial mesenchymal transition
endoplasmic reticulum stress
cell cycle arrest
cell death
high glucose
long non coding rna
drug induced
endothelial cells
cataract surgery