Palladium-Catalyzed Preparation of N -Substituted Benz[ c , d ]indol-2-imines and N -Substituted Amino-1-naphthylamides.

Here, we report a novel and facile protocol for the synthesis of benz[ c , d ]indol-2-imines via palladium-catalyzed C-C and C-N coupling of 8-halo-1-naphthylamines with isocyanides in a single step. The reaction features broad substrate scopes and mild conditions, providing an efficient alternative for the construction of antiproliferative agents and BET bromodomain inhibitors. If 0.1 mL of H 2 O was added to this reaction, the N -substituted amino-1-naphthylamides could be obtained easily.