Enhanced Insulin Secretion Through Upregulation of Transcription Factors by Hydroalcoholic Extract of Securigera securidaca Seeds in Diabetic Animal Model.
Maryam HasaniEbrahim Abbasi-OshaghiFatemeh KhomariBahar KianiFatemeh MirzaeiIraj AlipourfardIraj KhodadadiHeydar TayebiniaMohammad BabaeiShahin Alizadeh-FanalouElham BahreiniPublished in: Endocrinology, diabetes & metabolism (2024)
HESS elicits an increase in insulin secretion through the mitigation of oxidative stress and tissue damage, as well as the modulation of gene expression related to the insulin transcription factors PDX-1 and MafA.
Keyphrases
- oxidative stress
- transcription factor
- gene expression
- type diabetes
- diabetic rats
- dna binding
- dna damage
- ischemia reperfusion injury
- dna methylation
- climate change
- induced apoptosis
- cell proliferation
- poor prognosis
- glycemic control
- signaling pathway
- wound healing
- heat shock
- skeletal muscle
- insulin resistance
- long non coding rna