Coexpression Analysis of Transcriptome on AIDS and Other Human Disease Pathways by Canonical Correlation Analysis.
Yahong ChenJinjin YuanXianlin HanXiao-Long LiuXiao HanHanhui YePublished in: International journal of genomics (2017)
Acquired immune deficiency syndrome is a severe disease in humans caused by human immunodeficiency virus. Several human genes were characterized as host genetic factors that impact the processes of AIDS disease. Recent studies on AIDS patients revealed a series disease is complicating with AIDS. To resolve gene interaction between AIDS and complicating diseases, a canonical correlation analysis was used to identify the global correlation between AIDS and other disease pathway genes expression. The results showed that HLA-B, HLA-A, MH9, ZNED1, IRF1, TLR8, TSG101, NCOR2, and GML are the key AIDS-restricted genes highly correlated with other disease pathway genes. Furthermore, pathway genes in several diseases such as asthma, autoimmune thyroid disease, and malaria were globally correlated with ARGs. It suggests that these diseases are a high risk in AIDS patients as complicating diseases.
Keyphrases
- antiretroviral therapy
- genome wide
- human immunodeficiency virus
- end stage renal disease
- endothelial cells
- ejection fraction
- newly diagnosed
- genome wide identification
- chronic kidney disease
- immune response
- gene expression
- hepatitis c virus
- poor prognosis
- prognostic factors
- peritoneal dialysis
- dna methylation
- long non coding rna
- bioinformatics analysis
- single cell
- early onset
- air pollution
- microbial community
- network analysis
- case report
- antibiotic resistance genes