Renal changes in COVID-19 infection.
Pastora Maria de Araújo DuarteFrancisco André Gomes Bastos FilhoJoão Vitor Araujo DuarteBeatrice Araújo DuarteIsabella Araujo DuarteRomélia Pinheiro Gonçalves LemesFernando Barroso DuartePublished in: Revista da Associacao Medica Brasileira (1992) (2020)
The COVID-19 (SARS-CoV-2) infection started in China, Wuhan City, Hubei Province, in December 2019, and it was declared a pandemic in mid-March 2020, caused by a new coronavirus strain called SARS-CoV-2. The pathogenesis of kidney injury attributed to SARS- CoV-2 is not well defined yet. Observations show that the kidney damage caused by the new virus mutation is mainly tubular, with impairment of glomerular filtration and high levels of urea and creatinine. A study with seriously ill patients with COVID-19 showed that acute kidney injury was present in 29%. In the face of this evidence, based on recent studies, we can see the great renal contribution as an impact factor in the evolution of COVID-19, not just as a complicator of severity, but maybe part of the initial cascade of the process, requiring a deeper analysis using conventional biomarkers of kidney injury and more aggressive clinical intervention in patients at risk, in an attempt to reduce mortality.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- coronavirus disease
- acute kidney injury
- end stage renal disease
- ejection fraction
- newly diagnosed
- randomized controlled trial
- south africa
- prognostic factors
- cardiac surgery
- high glucose
- cardiovascular events
- type diabetes
- uric acid
- coronary artery disease
- patient reported
- disease virus