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A Programmable In Vivo CRISPR Activation Model Elucidates the Oncogenic and Immunosuppressive Functions of MYC in Lung Adenocarcinoma.

Fredrik I ThegeDhwani N RupaniBhargavi Brahmendra BarathiSara L ManningAnirban MaitraAndrew D RhimSonja M Wörmann
Published in: Cancer research (2022)
A streamlined platform for programmable CRISPR gene activation enables rapid evaluation and functional validation of putative oncogenes in vivo.
Keyphrases
  • genome wide
  • genome editing
  • crispr cas
  • transcription factor
  • dna methylation
  • copy number
  • high throughput
  • gene expression
  • quantum dots
  • single cell
  • clinical evaluation