Insulin-Like Growth Factor 1 Receptor Drives Hepatocellular Carcinoma Growth and Invasion by Activating Stat3-Midkine-Stat3 Loop.

Caiqun BieYanfang ChenHuijun TangQing LiLu ZhongXiaojuan PengYing ShiJunqin LinJunlong LaiShenglan WuShao-Hui Tang

Published in: Digestive diseases and sciences (2021)

Constitutive activation of the IGF-1R-mediated Stat3-Midkine-Stat3 positive feedback loop is present in HCC, the inhibition of which can serve as a potential therapeutic intervention strategy for HCC.

Keyphrases

cell proliferation
randomized controlled trial
transcription factor
signaling pathway
binding protein
growth hormone
pi k akt