Characterization of inorganic phosphate transport in the triple-negative breast cancer cell line, MDA-MB-231.

Thais Russo-AbrahãoMarco Antônio Lacerda-AbreuTainá GomesDaniela Cosentino-GomesAyra Diandra Carvalho-de-AraújoMariana Figueiredo RodriguesAna Carolina Leal de OliveiraFranklin David RumjanekRobson de Queiroz MonteiroJosé Roberto Meyer-Fernandes

Published in: PloS one (2018)

Taken together, these results showed that the uptake of Pi in MDA-MB-231 cells is modulated by sodium and by regulatory mechanisms of intracellular sodium gradient. General Significance: Pi transport might be regarded as a potential target for therapy against tumor progression.

Keyphrases

cell cycle arrest
breast cancer cells
cell death
induced apoptosis
pi k akt
poor prognosis
transcription factor
signaling pathway
endoplasmic reticulum stress
reactive oxygen species
oxidative stress
stem cells
climate change
replacement therapy