Primary osteoarthritis chondrocyte map of chromatin conformation reveals novel candidate effector genes.
Norbert BittnerChenfu ShiDanyun ZhaoJames DingLorraine SouthamDiane SwiftPeter KreitmaierMauro TutinoOdysseas StergiouJackson T S CheungGeorgia KatsoulaJenny HankinsonJeremy Mark WilkinsonGisela OrozcoEleftheria ZegginiPublished in: Annals of the rheumatic diseases (2024)
We have constructed the first Hi-C map of primary human chondrocytes and have made it available as a resource for the scientific community. By integrating 3D genomics with large-scale genetic association and epigenetic data, we identify novel candidate effector genes for osteoarthritis, which enhance our understanding of disease and can serve as putative high-value novel drug targets.
Keyphrases
- genome wide
- dna methylation
- rheumatoid arthritis
- gene expression
- regulatory t cells
- endothelial cells
- dendritic cells
- knee osteoarthritis
- healthcare
- bioinformatics analysis
- genome wide identification
- wastewater treatment
- transcription factor
- mental health
- type iii
- copy number
- single cell
- high density
- molecular dynamics simulations
- big data
- emergency department
- genome wide analysis
- machine learning
- extracellular matrix
- pluripotent stem cells
- data analysis
- drug induced
- adverse drug
- crystal structure