Anti-inflammatory protective effect of ADAMTS-13 in murine arthritis models.
Shoichi FukuiSarah GutchSaeko FukuiLong ChuDenisa D WagnerPublished in: Journal of thrombosis and haemostasis : JTH (2022)
Our results demonstrate the inhibitory role of Adamts13 in murine arthritis and the effectiveness of rhADAMTS-13 treatment. Additionally, this study suggests that deposition of VWF in the synovium and subsequent pathogenic NET retention promotes arthritis. Treatment with rhADAMTS-13 provides a potential therapeutic approach targeting inflammation and pro-thrombotic state in arthritis.