Current trends in chemical modifications of magnetic nanoparticles for targeted drug delivery in cancer chemotherapy.
Ahmad GolamiSeyyed Alireza HashemiYounes GhasemiWei-Hung ChiangNajmeh ParvinPublished in: Drug metabolism reviews (2020)
Nowadays, magnetic nanoparticles (MNPs) have been rapidly investigated and attracted worldwide attention due to their great potential as mediators of heat for treating hyperthermia and their possibility to deliver drugs at specific locations, which can thereby limit systematic effects. Cancer therapy via MNPs proposes novel properties rather than normal methods such as almost zero side effects and a high-efficiency rate of effectiveness. The key aim of targeted drug delivery is to reduce side effects of the main cancer treatment that other usual chemotherapies will attend to the body, and thus controlling the effectiveness of the drug on a specific location that tumoral tissue exist. Herein, the high potential of MNPs has been studied, and different examples of their effectiveness on drug delivery and hypothermia therapy have been provided.
Keyphrases
- cancer therapy
- drug delivery
- magnetic nanoparticles
- high efficiency
- randomized controlled trial
- systematic review
- drug release
- working memory
- cardiac arrest
- emergency department
- human health
- squamous cell carcinoma
- stem cells
- locally advanced
- risk assessment
- heat stress
- rectal cancer
- atomic force microscopy
- high speed
- smoking cessation
- lymph node metastasis