Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade.

Claire ConcheFabian FinkelmeierMarina PešićAdele M NicolasTim W BöttgerKilian B KennelDominic DenkFatih CeteciKathleen MohsEsther EngelÖzge CanliYasamin DabiriKai-Hendrik PeifferStefan ZeuzemGabriela SalinasThomas LongerichHuan YangFlorian R Greten

Published in: Gut (2023)

Our data highlight a context-specific ferroptosis-induced immune response that could be therapeutically exploited for the treatment of primary liver tumours and liver metastases.

Keyphrases

liver metastases
immune response
cell death
high glucose
electronic health record
big data
toll like receptor
artificial intelligence
replacement therapy