Upregulation of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in renal tissue in severe dengue in humans: Effects on endothelial activation/dysfunction.
Webster Oliveira VitoriaLetícia Silva ThoméLuciane Kanashiro-GaloLeda Viegas de CarvalhoRicardo PennyWashington Luis Conrado SantosPedro Fernando da Costa VasconcelosMirian Nacagami SottoMaria Irma Seixas DuarteJuarez Antonio Simões QuaresmaCarla PagliariPublished in: Revista da Sociedade Brasileira de Medicina Tropical (2019)
The results appear to demonstrate an imbalance between vascular endothelial permeability regulating events in renal lesions in SD. The increase in the expression of ICAM-1 and VCAM-1 is an in-situ indicator of higher permeability with a consequent influx of cells favoring the inflammation of the endothelium. These molecules are important in the pathophysiology of the disease and provide the possibility of developing new markers for the evaluation, clinical follow-up, and therapeutic response of patients with SD.