Evaluating the effect of vitamin D supplementation on serum levels of 25-hydroxy vitamin D, 1,25-dihydroxy vitamin D, parathyroid hormone and renin-angiotensin-aldosterone system: a systematic review and meta-analysis of clinical trials.

Alireza KhodadadiyanMahdi RahmanianDorsa ShekouhMelika GolmohammadiArshin GhaediAida BazrgarMehrab SayadiMehdi BazrafshanAigin HeydariHamed Bazrafshan Drissi

Published in: BMC nutrition (2023)

Vitamin D supplements significantly increase the serum levels of 25(OH)D and 1,25(OH)2D and decrease PTH levels. While some studies reported decreasing effect of vitamin D supplements on RAAS activity, some reported no changes.

Keyphrases

clinical trial
angiotensin ii
randomized controlled trial
open label
study protocol
case control
phase iii