Up-regulation of indoleamine 2,3-dioxygenase 1 (IDO1) expression and catalytic activity is associated with immunosuppression and poor prognosis in penile squamous cell carcinoma patients.

Qiang-Hua ZhouHui HanJia-Bin LuTing-Yu LiuKang-Bo HuangChuang-Zhong DengZai-Shang LiJie-Ping ChenKai YaoZi-Ke QinZhuo-Wei LiuYong-Hong LiSheng-Jie GuoYun-Lin YeFang-Jian ZhouRan-Yi Liu

Published in: Cancer communications (London, England) (2020)

IFNγ-induced IDO1 plays a crucial role in immunoediting and immunosuppression in PSCC. Additionally, serum KTR, an indicator of IDO1 catabolic activity, can be utilized as an independent prognostic factor for PSCC.

Keyphrases

poor prognosis
prognostic factors
long non coding rna
squamous cell carcinoma
end stage renal disease
chronic kidney disease
newly diagnosed
ejection fraction
immune response
dendritic cells
prostate cancer
high glucose
patient reported outcomes
lymph node metastasis
patient reported