MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice.
Sanjeev Kiran GotruElmina Mammadova-BachGeorgios SogkasMichael K SchuhmannKaren SchmittPeter KraftSabine HerterichMedina MamtiminAkif PinarciSarah BeckSimon StrittHan ChaoPengxuan RenJean-Noël FreundChristian KlemannFelix C C RingshausenJohan W M HeemskerkAlexander DietrichBernhard NieswandtGuido StollThomas GudermannAttila BraunPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
These results suggest that MAGT1 and TRPC6 are functionally linked. Therefore, deficiency or impaired functionality of MAGT1 could be a potential risk factor for arterial thrombosis and stroke.