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Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways.

Ziyun WuMegan M SenchukDylan J DuesBenjamin K JohnsonJason F CooperLeira LewEmily MachielaClaire E SchaarHeather DeJongeT Keith BlackwellJeremy M Van Raamsdonk
Published in: BMC biology (2018)
Our results suggest that in the long-lived mitochondrial mutant nuo-6 activation of the mitoUPR causes atfs-1-dependent changes in the expression of genes involved in stress response and metabolism, which contributes to the extended longevity observed in this mutant. This work demonstrates that the mitoUPR can modulate multiple stress response pathways and suggests that it is crucial for the development and lifespan of long-lived mitochondrial mutants.
Keyphrases
  • oxidative stress
  • transcription factor
  • wild type
  • poor prognosis
  • binding protein
  • endoplasmic reticulum stress
  • drosophila melanogaster