3-Aminobenzamide Prevents Concanavalin A-Induced Acute Hepatitis by an Anti-inflammatory and Anti-oxidative Mechanism.

Joram WardiOrna ErnstAnna LiljaHussein AeedSebastián KatzIdan Ben-NachumIris Ben-DrorDolev KatzOlga BernadskyRajendar KandhikondaYona AvniIain D C FraserRoy WeinstainAlexander BiroTsaffrir Zor

Published in: Digestive diseases and sciences (2018)

Our results suggest that 3-AB has a therapeutic effect on concanavalin A-induced liver injury by inhibiting expression of the key pro-inflammatory cytokine TNFα, via PARP-1-independent NFκB suppression and via an NFκB-independent anti-oxidative mechanism.

Keyphrases

signaling pathway
lps induced
anti inflammatory
pi k akt
poor prognosis
oxidative stress
nuclear factor
rheumatoid arthritis
dna damage
high glucose
diabetic rats
dna repair
inflammatory response
drug induced
mouse model
binding protein
long non coding rna
cell proliferation