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AF9 sustains glycolysis in colorectal cancer via H3K9ac-mediated PCK2 and FBP1 transcription.
Xuefeng He
Xinyang Zhong
Yi Fang
Zijuan Hu
Zhiyu Chen
Yaxian Wang
Huixia Huang
Senlin Zhao
Dawei Li
Ping Wei
Published in:
Clinical and translational medicine (2023)
AF9 is essential for the upregulation of PCK2 and FBP1, and the disruption of the miR-145/AF9 axis may serve as a potential target for the development of CRC therapeutics.
Keyphrases
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atrial fibrillation
cell proliferation
long non coding rna
poor prognosis
small molecule
transcription factor
long noncoding rna
signaling pathway