Rhodiola crenulata reduces ventricular arrhythmia through mitigating the activation of IL-17 and inhibiting the MAPK signaling pathway.

Ya-Wen HsiaoYung-Nan TsaiYu-Ting HuangShuen-Hsin LiuYenn-Jiang LinLi-Wei LoYu-Feng HuFa-Po ChungShien-Fong LinShih-Lin ChangSatoshi HigaShih-Ann Chen

Published in: Cardiovascular drugs and therapy (2020)

RC inhibited the expression of IL-17 and its downstream target genes that were mediated by activation of several MAPKs, which decreased the levels of fibrosis and apoptosis and suppressed VA.

Keyphrases

signaling pathway
pi k akt
oxidative stress
cell cycle arrest
poor prognosis
epithelial mesenchymal transition
induced apoptosis
heart failure
endoplasmic reticulum stress
left ventricular
catheter ablation
cell death
genome wide
gene expression
binding protein
atrial fibrillation