Increased uptake of the P2X7 receptor radiotracer 18 F-JNJ-64413739 in the brain and peripheral organs according to the severity of status epilepticus in male mice.
James MorganOscar MorenoMariana AlvesZuriñe BazAida Menéndez MéndezHanna LeisterCiara MeliaJonathon SmithAlexander VisekrunaAnnette NickeAnindya BhattacharyaMarc CeustersDavid C HenshallVanessa Gómez-VallejoJordi LlopTobias Engel Ayer BotrelPublished in: Epilepsia (2022)
Taken together, our data suggest that P2X7R-based PET imaging may help to identify seizure-induced neuropathology and temporal lobe epilepsy patients with increased P2X7R levels possibly benefitting from P2X7R-based treatments.