Upregulation of peripheral blood mononuclear cells resistin gene expression in severe obstructive sleep apnea and obstructive sleep apnea with coexisting type 2 diabetes mellitus.
Branislava RajkovMarija ZdravkovićAna NinicMilica BrajkovićSlobodan KlašnjaVera GardijanLidija MemonJelena MunjasMarija MihajlovićVesna Spasojević-KalimanovskaVojislav RadosavljevićMiron SopicPublished in: Sleep & breathing = Schlaf & Atmung (2023)
Resistin gene upregulation in S-OSA indicates its possible contribution to increased inflammation in S-OSA and makes it a possible marker of the disease severity. Resistin gene upregulation in OSA + T2DM suggests that a joint effect of these two comorbidities may have a major contribution to increased inflammation and complications that arise from this state.
Keyphrases
- obstructive sleep apnea
- positive airway pressure
- gene expression
- poor prognosis
- oxidative stress
- cell proliferation
- genome wide
- sleep apnea
- signaling pathway
- copy number
- dna methylation
- genome wide identification
- glycemic control
- long non coding rna
- risk factors
- early onset
- type diabetes
- skeletal muscle
- genome wide analysis
- weight loss