Ruthenium(ii)-catalyzed intermolecular annulation of alkenyl sulfonamides with alkynes: access to bicyclic sultams.

Lei-Lei QianXiang-Ting MinYan-Cheng HuBing-Xue ShenSa-Na YangBoshun Wan Qing-An Chen

Published in: Chemical communications (Cambridge, England) (2020)

A ruthenium-catalyzed allylic C(sp3)-H activation strategy has been employed to develop an intermolecular coupling of alkenyl sulfonamides with alkynes. This protocol features the diastereoselective construction of [3.3.0] and [4.3.0] bicyclic sultams in one step.

Keyphrases

room temperature
energy transfer
solid phase extraction
randomized controlled trial
ionic liquid
mass spectrometry
simultaneous determination
high density