Meta-Analysis of Genome-Wide Association Studies Reveals Genetic Mechanisms of Supraventricular Arrhythmias.
Lu-Chen WangShaan KhurshidAmelia Weber HallVictor NauffalValerie N MorrillYan V SunJoel T RämöDominik BeerSimon S K LeeGirish Nitin NadkarniRenee JohnsonLaura AndreasenAnne ClaytonClive R PullingerZachary T YonedaDaniel J FriedmanMatthew C HymanRenae L JudyAllan C SkanesKate M OrlandPaloma JordaTimothy M TreuMatthew T OetjensRajesh SubbiahJacob Peter HartmannHeidi T MayJohn P KaneTariq Ziad IssaNavid A NafissiPeter Leong-SitMarie-Pierre DubéCarolina RoselliSeung Hoan Choinull nullJean Claude TardifHabib Rehman KhanStacey KnightJesper Hastrup SvendsenBruce WalkerRichard Karlsson LinnérJohn Michael GazianoRafik TadrosDiane FatkinDaniel James RaderSvati H ShahDan M RodenGregory M MarcusRuth J F LoosScott M DamrauerChristopher M HaggertyKelly ChoAarno PalotieMorten Salling OlesenLee L EckhardtJason D RobertsMichael J CutlerM Benjamin ShoemakerPeter W F WilsonPatrick T EllinorSteven A LubitzPublished in: Circulation. Genomic and precision medicine (2024)
Our findings highlight gene regions associated with ion channel function (AVAP/AVRT), as well as cardiac development and the sarcomere (AVAP/AVRT and AVNRT) as important potential effectors of supraventricular tachycardia susceptibility.