Neuroendocrine modulation by metamizole and indomethacin: investigating the impact on neuronal markers and GnRH release.

The results of our study showing an increase in the expression of neuronal factors reveal that metamizole and indomethacin may have possible neuroprotective effects. Moreover, the effects on the GnRH expression appear to be different. Animal models are required to confirm these effects of NSAIDs on neurons.