The long noncoding RNA MALAT1 modulates adipose loss in cancer-associated cachexia by suppressing adipogenesis through PPAR-γ.

Jun HanLei ShenZheng ZhanYuguo LiuChang ZhangRuochen GuoYangjun LuoZhiqin XieYing FengGuohao Wu

Published in: Nutrition & metabolism (2021)

This study indicated that MALAT1 is associated with adipose loss in cancer-associated cachexia by regulating adipogenesis through PPAR-γ, which may potentially be a novel target for the diagnosis and treatment of cancer-associated cachexia in the clinic.

Keyphrases

long noncoding rna
insulin resistance
high fat diet induced
adipose tissue
fatty acid