Raman Spectroscopy, X-ray Diffraction, and Scanning Electron Microscopy as Noninvasive Methods for Microstructural Alterations in Psoriatic Nails.
Anca E ChiriacDoina AzoicaiAdina CoroabăFlorica DorofteiDaniel TimpuAnca ChiriacMihaela PerteaElena-Laura UrsuMariana PintealaPublished in: Molecules (Basel, Switzerland) (2021)
Psoriasis is a chronic inflammatory disease associated with immune system dysfunction that can affect nails, with a negative impact on patient life quality. Usually, nail psoriasis is associated with skin psoriasis and is therefore relatively simple to diagnose. However, up to 10% of nail psoriasis occurs isolated and may be difficult to diagnose by means of current methods (nail biopsy, dermoscopy, video dermoscopy, capillaroscopy, ultrasound of the nails, etc.). Since the nail is a complex biological tissue, mainly composes of hard α-keratins, the structural and morphological techniques can be used to analyze the human fingernails. The aim of this study was to corroborate the information obtained using Raman spectroscopy with those obtained by scanning electron microscopy (SEM) and X-ray diffractometry and to assess the potential of these techniques as non-invasive dermatologic diagnostic tools and an alternative to current methods.
Keyphrases
- electron microscopy
- raman spectroscopy
- oxidative stress
- endothelial cells
- atopic dermatitis
- magnetic resonance imaging
- rheumatoid arthritis
- ultrasound guided
- ankylosing spondylitis
- case report
- white matter
- climate change
- health information
- soft tissue
- induced pluripotent stem cells
- high resolution
- systemic lupus erythematosus
- quality improvement
- pluripotent stem cells
- drug induced