Gene expression associations with body mass index in the Multi-Ethnic Study of Atherosclerosis.

Luciana B VargasLeslie A LangeKendra FerrierFrançois AguetKristin ArdlieStacey GabrielNamrata GuptaJoshua D SmithThomas W BlackwellJingzhong DingPeter DurdaRussell P TracyYongmei LiuKent D TaylorW Craig JohnsonStephen S RichJerome I RotterEthan M LangeIain R Konigsberg

Published in: International journal of obesity (2005) (2022)

We have identified genes whose expression is significantly associated with obesity in a multi-ethnic cohort. We have identified novel genes associated with BMI as well as confirmed previously identified genes from earlier genetic analyses. These novel genes and their biological pathways represent new targets for understanding the biology of obesity as well as new therapeutic intervention to reduce obesity and improve global public health.

Keyphrases

weight gain
body mass index
genome wide
insulin resistance
metabolic syndrome
public health
weight loss
gene expression
high fat diet induced
type diabetes
bioinformatics analysis
genome wide identification
poor prognosis
cardiovascular disease
adipose tissue
physical activity
genome wide analysis