Gene-based interaction analysis shows GABAergic genes interacting with parenting in adolescent depressive symptoms.

Evelien Van AsscheTim MoonsOzan CinarWolfgang ViechtbauerAlbertine J OldehinkelKarla Van LeeuwenKarine VerschuerenHilde ColpinDiether LambrechtsWim Van den NoortgateLuc GoossensStephan ClaesRuud van Winkel

Published in: Journal of child psychology and psychiatry, and allied disciplines (2017)

We present a gene-based method for gene-environment interactions in a polygenic context and show that genes interact differently with particular aspects of parenting. This accentuates the importance of polygenic approaches and the need to accurately assess environmental exposure in G × E.

Keyphrases

genome wide identification
genome wide
depressive symptoms
copy number
genome wide analysis
dna methylation
transcription factor
mental health
physical activity
risk assessment
social support
sleep quality
protein kinase