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Comprehensive identification of somatic nucleotide variants in human brain tissue.

Yifan WangTaejeong BaeJeremy ThorpeMaxwell A ShermanAttila G JonesSean ChoKenneth DailyYanmei DouJavier GanzAlon GalorIrene LobonReenal PattniChaggai RosenbluhSimone TomasiLivia TomasiniXiaoxu YangBo ZhouSchahram AkbarianLaurel L BallSara BizzottoSarah B EmeryRyan DoanLiana FaschingYeongjun JangDavid JuanEsther LizanoLovelace J LuquetteJohn B MoldovanRujuta NarurkarMatthew T OetjensRachel E RodinShobana SekarJoo Heon ShinEduardo SorianoRichard E StraubWeichen ZhouAndrew ChessJoseph G GleesonTomas Marquès-BonetPeter J ParkMette A PetersJonathan PevsnerChristopher A WalshDaniel R Weinbergernull nullFlora M VaccarinoJohn V MoranAlexander E UrbanJeffrey M KiddRyan E MillsAlexej Abyzov
Published in: Genome biology (2021)
This study provides a unified set of best practices to detect somatic SNVs in non-cancerous tissues. The data and methods are freely available to the scientific community and should serve as a guide to assess the contributions of somatic SNVs to neuropsychiatric diseases.
Keyphrases
  • copy number
  • healthcare
  • primary care
  • mental health
  • gene expression
  • electronic health record
  • genome wide
  • dna methylation
  • machine learning
  • artificial intelligence