Adipose tissue plays a central metabolic role in systemic energy metabolism via nutrient exchange and secretion of adipose-derived hormones and cytokines. Adipose tissue dysfunction increases the risk of developing conditions, including type 2 diabetes, coronary artery disease, stroke, and cancer, ultimately shortening healthy lifespan. Maintaining adipose tissue functions has recently garnered attention as a means to extend healthy life expectancy. We previously developed a T-cell activation-inhibitory assay, which facilitates efficient selection of candidate substances for extending healthy lifespan. Using this assay, we identified two candidate substances: Cynandione A (CA), a major component of Cynanchum wilfordii, and N-caffeoyltryptophan (NCT) found in coffee. This review summarizes recent findings regarding the effect of CA and NCT on adipocyte (the primary cells in adipose tissue) function, and their potential contribution to extending healthy life expectancy.
Keyphrases
- adipose tissue
- insulin resistance
- high fat diet
- type diabetes
- coronary artery disease
- drinking water
- high throughput
- induced apoptosis
- metabolic syndrome
- cardiovascular disease
- atrial fibrillation
- oxidative stress
- skeletal muscle
- percutaneous coronary intervention
- protein kinase
- cell cycle arrest
- glycemic control
- cell death
- acute coronary syndrome
- fatty acid
- blood brain barrier
- endoplasmic reticulum stress
- single cell
- coronary artery bypass grafting