Genomic Space of MGMT in Human Glioma Revisited: Novel Motifs, Regulatory RNAs, NRF1, 2, and CTCF Involvement in Gene Expression.

Mohammed A Ibrahim Al-ObaideViswanath ArutlaManny D BacolodWei WangRuiwen ZhangKalkunte S Srivenugopal

Published in: International journal of molecular sciences (2021)

We provide the first evidence for several new regulatory components in the MGMT gene locus which predict complex transcriptional and posttranscriptional controls with potential for new therapeutic avenues.

Keyphrases

gene expression
transcription factor
copy number
endothelial cells
dna methylation
genome wide identification
oxidative stress
genome wide
induced pluripotent stem cells
pluripotent stem cells