A prospective cohort study of Cutaneous Leishmaniasis due to Leishmania major: Dynamics of the Leishmanin skin test and its predictive value for protection against infection and disease.

Jihene BettaiebAmine ToumiWissem GhawarSadok ChlifMariem NouiraNabil Belhaj-HamidaAdel GharbiNissaf Ben-AlayaDhafer LaouiniHechmi LouzirKoussay DellagiAfif Ben Salah

Published in: PLoS neglected tropical diseases (2020)

Our findings confirm LST as a good tool for assessing L. major cryptic infection. However, the instability of the LST positivity in new foci should be considered as an important confounder of the outcome of this infection when developing a research protocol for vaccine trial.

Keyphrases

randomized controlled trial
clinical trial
study protocol
phase iii
open label
placebo controlled