α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1-42-stimulated murine astrocytes.

Taraneh EbrahimiMarcus RustSarah Nele KaiserAlexander SlowikCordian BeyerAndreas Rembert KoczullaJörg B SchulzPardes HabibJan-Philipp Bach

Published in: Journal of neuroinflammation (2018)

We conclude that Aβ1-42-stimulation results in an upregulation of NLRP3, caspase 1, and its cleavage products in astrocytes. A1AT time-dependently hampers neuroinflammation by downregulation of Aβ1-42-mediated NLRP3-inflammasome expression and thus may serve as a pharmaceutical opportunity for the treatment of Alzheimer's disease.

Keyphrases

nlrp inflammasome
poor prognosis
cell proliferation
signaling pathway
traumatic brain injury
cell death
cognitive decline
long non coding rna
cognitive impairment
induced apoptosis
lps induced
radiation therapy
combination therapy
dna binding
oxidative stress
transcription factor
subarachnoid hemorrhage