Monitoring of fusion gene transcripts to predict relapse in pediatric acute myeloid leukemia.
Hidemasa MatsuoYuka Iijima-YamashitaMiho YamadaTakao DeguchiNobutaka KiyokawaAkira ShimadaAkio TawaDaisuke TomizawaTakashi TagaAkitoshi KinoshitaSouichi AdachiKeizo HoribePublished in: Pediatrics international : official journal of the Japan Pediatric Society (2018)
Detection of MLL-AF9 transcripts on real-time quantitative polymerase chain reaction is a promising marker of relapse in pediatric AML. In contrast, the clinical utility of detecting AML1-ETO and CBFB-MYH11 expression is limited, although higher AML1-ETO expression can be a potential predictor of relapse when assessed according to an optimal threshold.
Keyphrases
- acute myeloid leukemia
- poor prognosis
- allogeneic hematopoietic stem cell transplantation
- free survival
- magnetic resonance
- high resolution
- long non coding rna
- heart failure
- copy number
- computed tomography
- dna methylation
- left ventricular
- transcription factor
- human health
- quantum dots
- sensitive detection
- genome wide analysis