Survivors with IR including prediabetes have less frequent zero CAC scores than insulin-sensitive survivors. Our study also showed that IR including prediabetes significantly increases the MESA 10-yr. CHD Risk with CAC in cancer survivors. This trial highlights the importance of screening survivors for IR and draws attention to the association of IR to CAC not only in diabetes but also in prediabetes. The high fraction of asymptomatic survivors with CAD is concerning and calls for further investigation. CAC scans are an inexpensive and efficient way of screening asymptomatic cancer survivors for CAD.
Keyphrases
- young adults
- type diabetes
- insulin resistance
- coronary artery disease
- childhood cancer
- glycemic control
- cardiovascular disease
- adipose tissue
- working memory
- study protocol
- computed tomography
- phase ii
- randomized controlled trial
- magnetic resonance imaging
- skeletal muscle
- polycystic ovary syndrome
- high fat diet induced
- emergency medical