Prenatal Metabolomic Profiles Mediate the Effect of Maternal Obesity On Early Childhood Growth Trajectories and Obesity Risk: the CANDLE Study.

Zunsong HuLuhang HanJiawang LiuJay H FowkeJoan C HanDavid KakhniashviliKaja Z LeWinnNicole R BushW Alex MasonQi Zhao

Published in: The American journal of clinical nutrition (2022)

Our study provided further evidence that prenatal metabolomic profiles might mediate the effect of maternal OWO on early childhood growth trajectories and OWO risk in offspring. The metabolic pathways including identified metabolite mediators might provide novel intervention targets for preventing the intrauterine development of obesity in offspring of mothers with obesity.

Keyphrases

insulin resistance
metabolic syndrome
weight loss
high fat diet induced
type diabetes
weight gain
high fat diet
birth weight
pregnant women
randomized controlled trial
body mass index