The oncogenic role of SAMMSON lncRNA in tumorigenesis: A comprehensive review with especial focus on melanoma.
Majid GhasemianHossein Babaahmadi-RezaeiAzam KhedriChandrabose SelvarajPublished in: Journal of cellular and molecular medicine (2023)
LncRNA Survival Associated Mitochondrial Melanoma Specific Oncogenic Non-coding RNA (SAMMSON) is located on human chromosome 3p13, and its expression is upregulated in several tumours, including melanoma, breast cancer, glioblastoma and liver cancer and has an oncogenic role in malignancy disorders. It has been reported that SAMMSON impacts metabolic regulation, cell proliferation, apoptosis, EMT, drug resistance, invasion and migration. Also, SAMMSON is involved in regulating several pathways such as Wnt, MAPK, PI3K, Akt, ERK and p53. SAMMSON is considered a potential diagnostic and prognostic biomarker in several types of cancer and a suitable therapeutic target. In addition, the highly expressed SAMMSON is closely associated with clinicopathological features of various cancers. SAMMSON has a significant role in regulating epigenetic processes by regulating histone protein or the status of DNA methylation. Herein for the first time, we comprehensively summarized the currently available SAMMSON, molecular regulatory pathways, and clinical significance. We believe that clarifying all the molecular aspects of this lncRNA can be a good guide for cancer studies in the future.
Keyphrases
- pi k akt
- cell proliferation
- dna methylation
- signaling pathway
- cell cycle arrest
- oxidative stress
- papillary thyroid
- transcription factor
- endothelial cells
- epithelial mesenchymal transition
- long non coding rna
- poor prognosis
- stem cells
- squamous cell
- binding protein
- cell cycle
- genome wide
- skin cancer
- long noncoding rna
- risk assessment
- young adults
- squamous cell carcinoma
- lymph node metastasis
- basal cell carcinoma
- free survival
- protein protein
- induced pluripotent stem cells