Development of multi-drug resistance to anticancer drugs in HepG2 cells due to MRP2 upregulation on exposure to menthol.

Katsuhito NagaiMayuko TamuraRyuga MurayamaShuhei FukunoTakuya ItoHiroki Konishi

Published in: PloS one (2023)

These results demonstrate that menthol causes hepatocellular carcinoma to acquire resistance to anticancer drugs such as EPI and CIS by MRP2 induction.

Keyphrases

poor prognosis
signaling pathway
drug induced