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Comments on "sensitivity of estimands in clinical trials with imperfect compliance" by Chen and Heitjan.

Stuart G BakerKaren S Lindeman
Published in: The international journal of biostatistics (2024)
Chen and Heitjan (Sensitivity of estimands in clinical trials with imperfect compliance. Int J Biostat. 2023) used linear extrapolation to estimate the population average causal effect (PACE) from the complier average causal effect (CACE) in multiple randomized trials with all-or-none compliance. For extrapolating from CACE to PACE in this setting and in the paired availability design involving different availabilities of treatment among before-and-after studies, we recommend the sensitivity analysis in Baker and Lindeman (J Causal Inference, 2013) because it is not restricted to a linear model, as it involves various random effect and trend models.
Keyphrases
  • clinical trial
  • randomized controlled trial
  • phase ii
  • neural network
  • data analysis