PICK1-Deficient Mice Maintain Their Glucose Tolerance During Diet-Induced Obesity.
Marie Balslev BackeRita Chan AndersenMorten JensenChunyu JinCecilie HundahlOksana DmytriyevaJonas T TreebakJakob Bondo HansenZach Gerhart-HinesKenneth L MadsenBirgitte HolstPublished in: Journal of the Endocrine Society (2023)
Our findings support the importance of PICK1 in overall hormone regulation. However, importantly, this effect is independent of the PICK1 expression in the β-cell, whereby global PICK1-deficient mice resist further deterioration of their glucose tolerance following diet-induced obesity.