Residual thymic tissue and lymph node involvement by acute myeloid leukaemia presenting as mediastinal, strongly 18 FDG-PET-positive masses.
Georg MaschmeyerIngo BrinkDoris JähneRenate ArnoldOlaf SchegaPublished in: European journal of haematology (2017)
We report on a multidisciplinary management of a 68-year-old AML patient presenting with a PET-positive mediastinal tumour typical for lymph node metastasis. It was removed via minimally invasive thoracoscopic intervention and was identified as a thymus residual infiltrated by AML. Follow-up PET-CT scan after resection and remission induction chemotherapy was completely normal. To our knowledge, this is the first documented case report of AML presenting with PET-positive infiltrates of thymic and lymph node tissue along the aortic bow mimicking a second intrathoracic malignancy. Our observation indicates the usefulness of this imaging technique and supports clarification of these unusual findings in AML patients, in case of need also by invasive diagnostic procedures, to enable an adequate therapeutic decision.
Keyphrases
- pet ct
- lymph node
- acute myeloid leukemia
- case report
- lymph node metastasis
- positron emission tomography
- computed tomography
- allogeneic hematopoietic stem cell transplantation
- minimally invasive
- neoadjuvant chemotherapy
- sentinel lymph node
- end stage renal disease
- squamous cell carcinoma
- healthcare
- ejection fraction
- randomized controlled trial
- chronic kidney disease
- ultrasound guided
- high resolution
- pet imaging
- magnetic resonance imaging
- respiratory failure
- aortic dissection
- left ventricular
- bone marrow
- aortic valve
- dendritic cells
- immune response
- robot assisted
- liver failure
- drug induced
- acute respiratory distress syndrome
- locally advanced
- mechanical ventilation
- hepatitis b virus
- atrial fibrillation
- pulmonary arterial hypertension
- pulmonary hypertension
- contrast enhanced ultrasound