Impact of maternal protein restriction on Hypoxia-Inducible Factor (HIF) expression in male fetal kidney development.
Julia Seva GomesLeticia Barros SeneGabriela Leme LamanaPatricia Aline BoerJosé Antônio Rocha GontijoPublished in: PloS one (2023)
The current study supported that the programmed reduced nephron number in the 17-DG LP offspring may be related to changes in the HIF-1α signaling pathway. Factors that facilitate the transposition of HIF-1α to progenitor renal cell nuclei, such as increased NOS, Ep300, and HSP90 expression, may have a crucial role in this regulatory system. Also, HIF-1α changes could be associated with reduced transcription of elF-4 and its respective signaling path.
Keyphrases
- poor prognosis
- endothelial cells
- signaling pathway
- binding protein
- transcription factor
- high fat diet
- single cell
- epithelial mesenchymal transition
- heat shock protein
- cell therapy
- heat shock
- oxidative stress
- pi k akt
- type diabetes
- nitric oxide
- metabolic syndrome
- physical activity
- birth weight
- nitric oxide synthase
- mesenchymal stem cells
- stem cells
- induced apoptosis
- small molecule
- insulin resistance
- bone marrow
- drug induced
- cell proliferation
- amino acid