Carvedilol improves heart rate variability indices, biomarkers but not cardiac nerve density in streptozotocin-induced T2DM model of diabetic cardiac autonomic neuropathy.

Olawale Mathias Akinlade Bamidele Victor OwoyeleOlufemi Ayodele Soladoye

Published in: Journal of basic and clinical physiology and pharmacology (2021)

Carvedilol improves physiological HRV indices and biomarkers but not structural lesions. Early detection of DCAN and intervention with carvedilol may prevent progression of autonomic neurologic sequel.

Keyphrases

heart rate variability
heart rate
diabetic rats
left ventricular
randomized controlled trial
oxidative stress
type diabetes
high glucose
high fat diet
blood pressure
drug induced
metabolic syndrome
endothelial cells
wound healing
peripheral nerve
skeletal muscle
glycemic control